Agreed, tuning is always the most difficult part. Plenty of guys with turbos on diesels have trouble tuning their compound setup properly. So many gauges are needed to do it correctly that most people skip a lot of it, then there's always the possibility (if not properly tuned) of having so much backpressure that you choke the engine OR force wastegates to open prematurely.
Tuning issues aside, the big advantage of a compound turbo setup is not the peak HP number (that's not a scientific way to rate a turbo anyway IMHO) but how quickly the boost comes on and how flat boost delivery can be. I doubt that a 58mm turbo on a 4.5l engine can spool before (pulling this out of my ass) 3000RPM. On an engine like the 1FZ, that's past the N/A torque peak and would result in lots of driver-felt turbo lag. With a smaller single you can spool up to 30psi before 2000rpm on a 4.5l motor but not have enough flow for the top end. A well matched and tuned compound setup can deliver plenty of boost throughout the entire RPM range without gross inefficiencies anywhere. In my mind I compare a well-tuned compound setup's boost delivery to that of a supercharger, but with much more intake air density and higher power potential
Lightweight turbines, compressors and VGT systems can all help the turbo spool faster and not choke as RPMs come up but you're still limited to a static compressor size and therefore map. There's always a compromise to be made and my point is that there are less compromises with a compound setup than with a single turbo, when talking about tuning and engine performance. Plumbing and fitment are more of a pain however.
I realize that my knowledge is in the context of diesel engines, but the concepts are the same, with the exception of how fueling affects combustion temperature (that's inverted between gas and diesel).
Rice should go with a smaller single IMHO, something around 50mm, for the boost levels he wants, to ensure that there isn't a lot of lag. 4500 redline is pretty low for a gas engine so a smaller turbo would serve him better. My 46mm turbo with 6cm2 turbine housing hits 30psi at 2000rpm, so I think the map would be a decent match but rice would want a larger turbine housing, somewhere between 9-12cm2. Unfortunately I don't know how Holset turbine housing dimensions map to Garret turbine housing dimensions, but Garret has that sweet turbine map calculator tool, so Rice can play with that to see where he wants his boost to come on. This is slick as s***:
Garrett Boost Adviser - Online | Turbobygarrett