if you make the ecms and tcm compatible to talk yes not an an ecu, that your just using the factory tuning, like you would be on a cheater, however the cheater allows you to run it standalone, and use an older ecm that allows drive by cable versus drive by wire
another thing to factor in
2007-2009 T-43's will only accept OS's from those years, and the 2010-up T-43's will only take OS's from those years. If you try to program an OS outside the year range for the T-43 you have, it will come up with an error and abort programming... Been there. you will need a TCM from the same year as the ECM and use an OS for that year. Should be good then... Good luck!
Or run a cheater cable from TCI and call it a day..... lol
My trans is from a 2010 and up truck, so we can run the correct OS and have my GM tech flash whatever software we want.
We are running a new ECM with drive by wire. Basically we will run my computer like it is a CTSV with a 6L90E
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