I just did this on our 2003 Sequoia this weekend (both sides). Not a ton of fun, but probably marginally easier than on a 100 series.The funnest stuff today - driver's side exhaust manifold! Took me all of 6 hours. Removed motor mount (both parts) (replaced with new). That made it a lot easier. Totally rust free truck was nice. No broken bolts or nuts. Probably could have done it in 5 if I had realized that the new manifold didn't have the exhaust pipe studs in it...and I spent at least 15 mins trying to disconnect the O2 sensor. VVTi and AHC. Yay! But no more clicking. Have the passenger as well, but I'll hold off. No special tools needed, but I have a pretty good assortment.
I hadn't originally planned on doing exhaust manifolds (though, had them sitting on the shelf), but as it turns out, by the time you're able to get the engine isolators/mounts off of a Sequoia the manifolds are right there. Unlike a 100 where you're able to swap the engine mounts without taking the bracket off that goes between the isolator/mount (the part we swap out) and the actual engine block, you have to take that whole bracket assembly off of the engine block itself to swap out the isolator on a first gen Sequoia, at least on the passanger side.