It's a balance of concerns and it's very possible to go too far. Part of the criticisms of 8-speed owners is already that there's too much gearing on the bottom end. And too many shifts. Evidenced by comments of shift smoothness and preference for the 6-speed. Focusing on highway cruise is going to miss issues with drivability around town, part throttle low speed downshifts, etc.
There's also the aspect of tuning. The transmission tuning was designed around assumptions of speed and load for various gears. Can't just drop in that dramatic of a change and expect it all to work. Even minor tailoring can result in unexpected changes to shift quality and torque converter lockup.
Maybe it can help to put this into perspective. 4.3s to the 8-speed is equivelent to 5.29s on the 6-speed. No one is asking for that. Maybe with 42" tires?
I've read a lot of your posts on towing and I'd like your thoughts on re-gearing as it relates to towing MPG. I have a ~4,000lb camper that I recently took on a road trip and the gas mileage drop was horrendous(2013 LX). I had to slow way down to 60-65 and then I could get 11ish MPG, but that speed is pretty painful for me.
I'm on 33" tires, and I saw in one of your posts that you air higher when towing. I will try that next time. I realize the answer is probably to suck it up and keep it slow, but I was wondering if a re-gear would help the MPG specifically. I do plan to go to 35s eventually.