We put ours on and take it off all the time. No issues there. Build quality is very good. Better than the Thule, IMO. And i have a Thule bike rack, so I'm brand agnostic. Yakima feet wrap all the way around the bars on our QX80.I did consider that one, but I'll be putting this thing on/off all the time. Per Outdoor Gear Lab: "However, the initial installation is quite a pain. It is still totally doable, but if you are planning on leaving the box off of your car most of the time, then throwing it on for a weekend getaway, you will probably be better served by a product that is a bit easier and more convenient when it comes to installation. If you plan on leaving the cargo box installed on a semi-permanent to permanent basis, the more laborious installation procedure shouldn't be a deterrent at all, and you should stick with the SkyBox and spend a little less."
The other thing that makes me prefer the Thule are the mounts. They grab on both sides of the bar they sit on, where the Yakima grabs on one side.
I remember seeing someone try to use the Yakima on a roof rack (I think it was prinsu?) and the feet don't fold all the way around. They just sort of "clamp" the bars, which makes it look like hard acceleration could send the box flying. The Yakima website fitting guide also says they can't guarantee fit on 3rd party racks, probably for this reason. I might be wrong though.