When I did my swap in '96, the NV4500 would have been my first choice had it not been for: 1) the cost at the time. 2) loss of 2nd gear.
Compared to a stock Toyota 4 speed, the NV4500: has a lower first gear, second's ratio is close to the Toyota 1st, third is comparable to Toyota 3rd, forth - forth, and fifth is an overdrive.
Wheeling I found I used second a lot and didn't want to loose that. Also, they were stupid expensive at the time.
Having been driving with a SBC for 27 years now... I've found its powerband is enough wider that loosing 2nd wouldn't be a great loss. And even $2500 isn't nearly so bad these days. So I'd say go for it. Perhaps use a centered diff and avoid using adapters. I'd guess an FJ rear axle or something similar would be easy to adapt to fit.