Gregnash,
I would say go for it if you have some basic fabrication skills. You will need to be able to weld up some motor mounts and various other brackets and such. If you have some decent mechanical reasoning and some engine experience, you will probably have no problem at all with this swap.
That being said, let me qualify my experience level before this swap. I grew up with a dad who was a top fuel drag racer and engines were always being torn down in front of me and I had to help from a young age. I work as a Firefighter, but I was a machinist/gunsmith for many years before this, so intricate mechanisms and mechanical systems are no problem for me.
Only you can decide if it is within your skill level, but if you decide to jump into this, you will learn an enormous amount from your first engine swap and you will have a lot of personal pride in building a truck that others could only imagine.
If it is not your daily driver, I would say go for it. There are a bunch of us on here that would help you with whatever obstacle you encounter. That is what I did and I had never done an engine swap before this one, let alone rebuild a diesel engine. The guys on this site are incredibly helpful and so are the guys on 4BTswaps.com. All of the guys that Doug mentioned above helped me as I was doing my swap and all of us will help you with whatever you need if you decide to go for it. Doug's thread in his sig line is just about the best one for documentation of this swap. His is like the how to bible for Isuzu swaps.
Have fun!
Don