I have to side with Ryan on this. I am by no means a staunch defender of the 3.0, but I think it has gotten a bit of a bad wrap. I think it was a rush job to compete with the other companies that were starting to release small v6s in the mid 80's and in my opinion the 3.4 is just an improved 3.0. I have built two of these motors and as Sam mentioned the vacuum lines on the manifold border on maddening, but if the heads are true and good HG's are used it will serve you well. Sidebar is there is little to no power to be "built" into one of these motors. The head design was pretty bad out of the box and OS valves and a port job will help, bit are not worth the investment IMO.
As far a doing the HG and timing belt, once you have the upper intake out of the way you are good. The #6 failure is primarily due to poorly designed cross-over connection of the exhaust. The PS bank dumps in right on #6 which causes problems with heat on that cylinder, valves, HG, etc. A set of headers or a minor exhaust rerouting can resolve most of those issues.
For me a 3.0 wouldn't be my first choice, but having fooled with them some they can be good little motors. Quieter than the clattery 22re, but much more finicky. If you are looking at one I would call Sam and price a set of gaskets and a timing belt setup and then you can have an idea of where you will be on the other end of it.
Again, I will stress this, don't chase power. Just tune it up good and realize it is what it is.
22re is a hard swap due to mounts, bell-housing/ transmissions, computers, etc. As others have said the 3.4 is the route for a swap, do some reading and you will see it has been done enough that it is about as close to a direct swap as it can be, but still not. Good luck