I had a 97 4runner with a 3.4, auto, slight lift, skids, sliders and 265's on 4.30 gears, my current 80 series is a 93, with sliders, about 2.5 inches of lift and 285's on stock 4.10's. I find more interior space to be nice for a daily driver (though not necessary) and I like the seating position of the 80 better, but I'm a small dude. Driving wise, the 4runner was superior in almost every way; less noise, 'lighter' feeling, rode better, and was more fuel efficient. The smaller size was easier to handle, though I don't think the 80's size is difficult to handle
I've driven both trucks long distances and despite the differences, the 4runner was better for me. It seemed better at running higher speeds (70-80mph) was more fuel efficient, and seemed to handle crappy highways better. With that being said, the difference was as astounding as I thought it would be, and I really love driving my 80. I do really miss that 4runner though, it was the perfect combo daily driver/wheeler.