Part of the difference to your previous experience is that the 5.7L is a brute and makes more torque and power off idle than every other Toyota model/drivetrain. An SC is only going to add to that. The 5.7L doesn't need the type of gearing that lower end models do, including the GX, to be setup for significant overland weight.
I've already shared - I do a lot of towing and overland trips. 15,620lbs combined weight when towing with 35s. 4.3 is perfect. 4.88 would be excess RPM, on the freeway in 6th gear when unladen.
To put things in perspective as these are not minor adjustments we're talking about
- 4.3 is a 10% correction to stock 3.9s
- 4.88 is a 25% correction to stock 3.9s
- 4.88 is 15% more gearing than 4.3! Let that sink in, 15% more is almost like a whole ratio in the 6-speed transmission. It would be like permanently rolling in 5th without the ability to grab 6th on the highway.
4.3s will give you your cake. It's not just gearing, as shift logic and torque lockup will behave like stock and not feel like a 10 yr old tuned the transmission.
It’s worth pointing out what kind of highway speeds you tend to do, what type of terrain, etc. Pulling 55mph along the CA coast is a bit different from pulling 80mph through the mountain west.