I'd like to do a before and after test of coil "health". Would be nice to find someone with high end shop testing equipment that shares my curiosity.
2001lc I am sure there is a way to test the coils with a multimeter. I have been told to replace coils as preventative maint at 200k. I don't put many miles on so I will just run it till I hear an issue. Read on "Bob is the oil guy" one time that chevron techtron is the only cleaner that actually has chemestry. I believe that fuel filter should be changed more frequently as well. Did you change anything else when you saw a drop in gas mileage(ex tires)?
So far in this thread it does seem that ~200K is the average we start seeing failures. I hope we get many more testimonials here to draw from.
I added some links to OP. One shows millimeter the another more specialize on engine coil testing. Both have merit, but I'd think the on engine would be the most reveling. Be interesting to do on engine coil test of high millage, then replace with new OEM and retest, coupled with MPG data don't you think?
I'll take a look (Bob***) on Chevron Techtron, thanks for the heads up. I've just been sold on BG product like 44K forever, may be time for a change.
I did a ~95K baseline; both belts (no W-pump) along with all idler & tensioner pulleys, spark plus and all filters, fluids and lubes. After this time I first documented a drop in MPG. I've since changed out front O2's (no code) and fuel filter (a second time) with no change in MPG or performance. I've logged differences with/in/of tires, air conditioning use, cabin fan use along with experimenting on fluids, lubes & grease to see viscosity variance over the years in MPG.
My LC runs very well but MPG is on a declining curve. MPG is actually good, but it has room for improvement IMHO. MPG is a reflection of performance of "parts" of these very integrated systems.
Which parts is the question. IMHO the combustion chamber is key and some post here defiantly point to weak (not failed) coils as a large suspect contributor to reduced performance.
This is anecdotal at best, but my wife's Cadillac CTS uses Bosch ignition coils as OEM and I've replaced 4 of 6 well before 90k. Granted, it's a filthy direct injection engine and a total POS so there may not be a quality correlation.
So many companies that start out offering a great produce, drop the ball when accounts pull the cost strings.
> The same reasons any coil will fail...primary reasons look to me to be engine heat, temperature changes, and vibration.
> I'd not replace gaskets, seals or grommets until / unless I saw weeping or leakage...same way I'd look at valve cover gaskets. Anecdotally, with ~180K miles on the '01 LX, she remains dry as a bone.
> I see no logic in replacing all coils if one goes bad. I would check the resistance on the remaining 7 and replace any that test out of the FSM spec range. That said, I do carry a spare. 
> No...failures are random enough that periodic resistance checks may catch impending failures.
> Imo, OEM.
All very good points. Starting with heat this is for sure IMHO the number one cause of failure. Rubber grommets & boot ageing (shrinkage & brittleness) would certainly accentuate vibration, brought on by age, heat & climate.
I'd add over or under voltage to coils, short along with fouled or improper spark plug gap contributing to coil failures.