I highly doubt a Turbo 4/hybrid powertrain will make me smile like my tuned 2UZ-FE with headers, a CAI, exhaust, and 4.56 gears does

. And that's coming from someone who has put thousands of miles on our NA 4-banger/hybrid Highlander. The Highlander is an exceptional good appliance (it's actually de-stressing to drive as it's so smooth/quiet), but it doesn't give a whole lot smiles, other than looking at the MPG meter (and when it takes $17 to fill it up!). But, I'll still test drive a LC250 in the future to confirm.
When I need a new SUV a used GX550 will be in the running. It's around 200# lighter than the LC250, has the bigger 9.5" rear diff, and a very good tow rating. I personally see the GX550 as more of a LC200 replacement than a GX460 replacement, as it's definitely a different class of vehicle than the 460 was in terms of size/power/tow capacity/drivetrain components.