I put P-metric 285/65/18 LTX Defenders M/S2 about 7000 miles ago (on OEM 18" wheels) on our 2015. Drove cross-country, including some snow and ice. I previously ran KO2 LT285/70/17 on Rock Warriors as well as P-metric studded Nokian Hakka 9 in 275/65/18 (P-metric) on this truck. On our 2021 I have LT Nitto Ridge Grapplers on 285/70/17 also on Rock Warriors.
I went with this tire since I wanted a quieter tire and one that is usable year round (I would not drive KO2s in winter). In fairness, the studded Nokians were overkill for New England, though they were awesome in bad conditions and also great on a winter rally course
Now the Michelins: most important difference - soft sidewalls! The ride is certainly plushier, which is particularly noticeable when bombing on dirt/gravels roads, but on highway speeds the handling suffers notably. I forgot how the truck handled on stock sized Michelins Latitudes that came with the truck when I bought it used 70k miles ago when I promptly switched to the KO2s. It is same, and maybe worse due to the extra sidewall (those tires were OEM sized, so 60 profile, and these are 65).
Fuel usage wise, I maybe gained 1 mpg. I drive the truck somewhat fast (~85 mph) and somewhat aggressively at times (yay, KDSS). It is possible to adjust to the softer tire, but I miss the handling of the LT tires. Even the Nokians seemed more sure footed.
Noise wise... technically they are not any quieter than KO2 (or even Nitto Grapplers), same db reading on the same patch of the road, however the type of noise they emit is nicer, though KO2 were never too objectionable (Grapplers do have mud-tire like hum).
In snow the Michelins have nothing on Nokians, but that's expected and no surprises here. Hit a patch of black ice on a curve, and got in a mild 4 wheel slide... was quite scary, but managed to control the truck. Again, it's not a winter tire, but it seemed worse than expected. I drove some distance on a snow covered dirt road with a mix of packed and fluffy snow, and I was sliding more than I liked or expected.
Then I also drove on a really muddy dirt road - it was a near disaster, I slid off the road into a deeper mud almost got stuck. But MTS/Crawl Control saved the day... It is definitely not a mud tire, which is even less of a surprise.
Overall, I like the tire more on the dirt roads than on highway, go figure. Perhaps should have bought this tire in the 17" LT version.