You can make drawers without roller bearing sliders. That way you loose less space. There is thread on someone who built drawers with a kind of synthetic slider under the drawers, which reportedly worked well.
If we end up doing drawers I have a few custom ideas to not loose any space to slides but we will see what we (my wife) decides on. I've seen Teflon plastic or uhmw plastic strips used with success, I wouldn't be scared to try that approach either.
The KISS system looks really well done, and uses a plastic slide I believe (UHMW I think?). Those components look like they come from the parts catalog for 80/20 Inc. (80/20 Inc. - T-slotted aluminum framing system). We use it at work quite a bit, and it is very versatile. The components exist inside an "ecosystem" where brackets, screws, extrusions, etc. are all designed to work together.
If I had one criticism for 80/20, it's that the extrusions can get heavy and expensive. But if you need that level of versatility, I don't know if there's anything better out there right now.