You can make drawers without roller bearing sliders. That way you loose less space. There is thread on someone who built drawers with a kind of synthetic slider under the drawers, which reportedly worked well.
If we end up doing drawers I have a few custom ideas to not loose any space to slides but we will see what we (my wife ) decides on. I've seen Teflon plastic or uhmw plastic strips used with success, I wouldn't be scared to try that approach either.
The KISS system looks really well done, and uses a plastic slide I believe (UHMW I think?). Those components look like they come from the parts catalog for 80/20 Inc. (80/20 Inc. - T-slotted aluminum framing system). We use it at work quite a bit, and it is very versatile. The components exist inside an "ecosystem" where brackets, screws, extrusions, etc. are all designed to work together.
If I had one criticism for 80/20, it's that the extrusions can get heavy and expensive. But if you need that level of versatility, I don't know if there's anything better out there right now.