You mentioned Isuzu...Well I installed a 4BD2Tc last summer and have been quite happy. Great performance, good fuel economy, very quiet, and a fairly easy install.
I kept the 3:70 gears and already had a H55 5 speed trans, so a 70 mph cruise is no issue. For people in SoCal or those who know Interstate 5 North of LA, I can drive the whole section to the central valley at 70+ mph in 5th the whole way no issue! Not to bad.
The engine has a great layout for a 60 swap...It just fits nice. For parts, any GM truck dealer can get parts, and most will service the engine. Isuzu has quite a few dealers and parts are not to bad price wise.
The 4BD1/2 engines were in many trucks in the US and can be found for very low prices. Overhaul kits are around $1,300.00 US and have press in liners and coated cranks. Stout engines with long lives. Some debate on which model is better/long lived, but both are good IMHO.
Check out 2BTswaps.com and go to the Isuzu section for great help and advice on these engines.
Check out the link under my signature for my swap with pictures. I think it looks almost factory and works factory, only better.
Just another option.
Good luck on your swap.
Doug