It will definitely make your engine work harder to get them up to speed which doesn't help mileage. Like kyot said though, I don't think there are gearing options available for those 2-speed axles; BUT the Columbia 2-speed rear axles (made for Ford) did come with 4:44 or 4:11 standard rear end ratio with 3:18 or 2:94 for the highway cruising. So if you got the proper (4.11) Columbia 2-speed axle for your 40, and you disengaged that front axle for the highway driving, you could hypothetically pull it off.