You know about body rust, all the usual spots where moisture can get trapped. Frame rust, generally right about the area where the cab and bed meet. 22R is a strong motor and there is plenty of support out there for them. Timing chain guides are made of plastic and fail allowing the timing chain to chew through the side of the timing cover.
You can get a new timing set (chain and gears) timing cover, metal chain guides, oil pump and water pump for $149.00. I did mine on a Sat afternoon. Check all fluids including gear cases and axles if you can, tells you a lot. Smell all the fluids, burnt smell is not good.
Pretty stout trans and T-case in those trucks, easy to add a double case. Lots of aftermarket support for these trucks.
Axles and brakes are standard fare and most likely will need attention as will tie rod ends etc.
