It's not so much the oil and more the compatibility of the additive packages. The additive packages control the multi-weight properties of the oil, and to a lesser extent extreme pressure additives that protect when the oil does shear, i.e boron, zinc, sulfur, etc, and foaming control, and detergent. That being said I don't think there are too many people that have had an issue or know anybody that has had an issue. As for mixing viscosities. Think of a container of oil like a room full of balls. The balls represent the polymer chains which dictate viscosity. Conventional oil would look like a room full of all size balls, basketballs, tennis balls, golf balls, bowling balls, ect. Synthetics have more evenly length polymer chains, i.e. a room full of only tennis balls.