Moving from up north, youll be familiar with personal property tax and state income tax. Those were new to me when we moved up from fl in 2000. Find a smaller town outside of a larger city. Summerfield is much better than Greensboro, even though they touch each other. Greensboro city has higher taxes than summerfield, and both have guilford county taxes. Had I known, I would have built in Summerfield vs Greensboro. Some counties have higher taxes than others, and some have stricter emissions on vehicles.
Spend a week or two roaming around to see what area you like. Mtns, sandhills/piedmont, or the coast. In the Triad (Greensboro, High Point, Winston Salem), we are about 3 hours from everything. Mtns are 3 hours or less away, beach is 3 hours away, Charlotte can be 3 hours away. Plus you get all kinds of town names that your wife will either laugh her butt off or be totally offended by to have on an address label. High Point, Climax, and Horneytown are just a sampling