You can use the dial indicator to get in the right area before you start fine tuning
I think there's a big difference in setting timing to spec, understanding where it's at, then tuning vs just getting in and giving it a random tweak
If it starts rattling and sounds like you have loose bolts in your rocker cover you've gone to far lol.
Yes it can have serious consequences if you get it wrong
If it's rattling, you've likely got a significant amount detonation happening before the piston reaches TDC on the compression stroke.
This means the pistons are compressing an expanding wall of combustion gas.
This hammers BEB, crank, crank bearings, pistons, and increases compression pressures, so hammers head bolts and head gaskets.
HD-T runs 20:1 static compression ratio, add 24psi boost and cylinder pressures are getting huge, add pre-detonation and you're asking a lot