Depends on the terrain and type of tyre damage you're expecting. A gash/stake on a sidewall can be too serious to repair with a plug. Then you need to get the rubber off the rim, splits make it so easy, but a decent tyre removal tool takes the drama out of that. R&R (oz) makes a nice bead breaker and tyre removal/reinstall tool.
I have splits in oz so tyrepliers work just fine. I take a couple of spare tubes and have various patches small to huge and FRESH vulcanizing fluid and the gear to be able to repair tubes and have never had the need for 2 spare tyres. I did take an (extra) spare tyre on a trip on the Canning stock route a bunch of years ago, never got a flat and never took an (extra) spare tyre again.
The issue with repairing large gashes in tyres is the silicone mold release agents that are on the inner part of the tyre - you MUST remove it to have a patch vulcanize. Search the web and you'll find good technical writeups that detail some of the steps involves in patching the inside of a tyre.
As Rosco states, the toyota or nissan split rims are not the scary things like big truck split rims. I generally inflate my splits with the split rim facing down - and whack the tyre with a rubber mallet as it inflates to properly seat the bead. A bit of soapy water helps with that too.
If you plan to be able to put a tube on a tubeless rim make sure you get a tube that will work with that rim. I'm assuming a tube may not work well (or at all) in a thick alloy rim.
From personal experience in the oz bush with splits and folk with tubeless steelies I prefer the splits but then I'm old and old school
With tube tyres you do need to ensure the inside is spotlessly clean or the tube will abrade against the tyre and rust ring/rim.
I guess in summary it's more a case of being familiar with the type of tyre/rim you are running and have the tools and experience to remove the tyre and repair the puncture. Whether it's a split rim or not becomes a lesser issue.
cheers,
george.