You have something seriously wrong if you are using that much fuel. I'm honestly not even sure how your truck is starting.
Sounds like your situation is a lot more than just rough running when cold. I think its time for a full baseline check of the engine....fuel pressure, vacuum, compression, valve clearance etc. If you know that mechanically the engine is trim and in spec then its a lot easier to go to the next step. 1/4 tank of fuel in 20 miles sounds like the EFI is at full injector duty cycle and you should be seeing a black cloud behind you. Your cats are likely toast by now if they are still on the truck.
Sounds like your situation is a lot more than just rough running when cold. I think its time for a full baseline check of the engine....fuel pressure, vacuum, compression, valve clearance etc. If you know that mechanically the engine is trim and in spec then its a lot easier to go to the next step. 1/4 tank of fuel in 20 miles sounds like the EFI is at full injector duty cycle and you should be seeing a black cloud behind you. Your cats are likely toast by now if they are still on the truck.