If you can figure out a t-case setup that will drop in you will be a rich man. The rear axle is offset like most all the cruisers. This combined with the gas tank location make all of the adapters and couplers useless without some serious mods. Marlin makes a low range gear set, as does Mark's offroad. Marks makes a doubler but it requires a good bit of fab work to accommodate. I have seen guys swap in manual transmissions and add divorced cases from earlier FJ series vehicles.
Both available low range gear sets also lower the high side gears too, so you end up slightly lower across the board.
I actually bought my 80 because we were expecting and needed another vehicle that could carry the family. We wheeled all day last fall with Baby girl sleeping comfortably in the back. With 5.29s, 35s in 1st gear low range the brakes had to work to stop it under idle.
As far as size, compared to an 85 it will look huge, but if you put it next to a 90-95 4 door, length isn't as noticeable, but they are a good bit wider. Interior room is nice to have when trucking around all the stuff that comes with a little one, and they make great expedition vehicles, so an arb fridge/freezer, etc. and you would be good for all weekend with room to spare.
It kinda depends on what your comfort level is. A decent 90-95 4runner could be built up into a nice rig. I will throw another wrench in the cogs and say for highway driving, the 22RE is going to be pretty taxed hauling around the extra weight of the later runners. Most of the came with the 3.0 V6, which has a pretty bad wrap, honestly I am not sure and I am rebuilding one for my 88 project now. An SAS is no problem with all the aftermarket support these days.
Speaking of aftermarket, that is one more thing about the 80 series, they do not have near the aftermarket support of the minis and as such the market is a little more specialized. Parts are not as easy to come by and tend to be a little more as well.