Interested to hear what settings you are running and how you like it after driving a little longer
I've been waiting to respond until I had more time and driving conditions under my belt, and I have now put about 200 miles on it in mixed city/highway driving since Sunday. In a word, the truck has been transformed.
There are 4 modes: eco, city, sport, sport plus, and within each mode you can dial it from -4 to +4. I have found sport +3 is perfect for me. Anything more it's a bit too twitchy, although sport plus turned up all the way is hilarious because it's so responsive, but it's essentially impossible to drive smoothly. Sport +3 is just about on par with the stock sensitivity of the 08 LX570 which is perfect IMO.
My wife recently borrowed the truck for a weekend, and I told her to take it for a spin after adding the Pedal Commander. She put it in drive, took her foot off the brake and eased into the gas pedal and literally within 2 seconds said "Whoa! What did you do??". She agrees it's a different truck and much more enjoyable to drive. I've never purchased a tuner, chip, or anything that manipulates the throttle like this, but I'm 100% sold now. If I was to buy another 16+ LC, this would literally be the first thing I bought for it even before Weathertech mats.
I'm very particular/sensitive to how vehicles drive, and one thing that has annoyed me with the two 200s I have is that in the Lexus the gas pedal is very sensitive (good) yet the brake pedal has more travel than I'd like (bad). The 16 LC has a great brake pedal feel that doesn't require nearly as much force, but the gas pedal used to require a lot more pressure than I'd like and essentially forced me to go deeper into the pedal travel to get it to accelerate and cruise the same way the Lexus does. I hate when there is a big disparity in pedal pressure between the two pedals next to each other, so I find it much more comfortable and easy to drive now.
Also I will need to do a full tank mpg test, but so far it appears I'm averaging a solid 2mpg better than before which is a material increase.