I just installed 6.5 components in my regular cab 88. It has the vent windows but, like the other guy said, it's pretty easy to make spacers if you have interference. Here are some pics/info I wrote up on UltimateYota:
I installed my deck that I bought a week or 2 ago. I found the exact same model that I have in the 4Runner on the clearance rack at Circuit City and I really like the deck so I figured I would run one here too. It was really cheap too. It is the JVC KD-G-420:
The other day I stopped by the local audio shop and talked to the guys there. I can build a pretty decent stereo system when I have some room but there is very little space to mount stuff in here. I had planned to get some middle of the road 4" for the dash and some 6.5"s for the doors straight off the deck. When I mentioned this to them they said that every time they have seen that setup in one of these trucks the 4" speakers actually make it sound worse because the mounting locations suck so much as far as acoustics. They said I would be better off getting some 6.5" components and an amp. They recommended some MB Quarts that, ironically, they had a whole pile of. I told them I would think about it. I went and researched them and everyone hates them for some reason. So, I kept searching and found some that seem to be a good compromise since I'm only going to have 2 speakers (plus they were on sale at Crutchfield). I settled on the Polk db6500s.. They'll hopefully be here in a few days:
I had an old Rockford 2 channel 150W amp that I used to run my subs off of. It did well and was in the range recommended for the Polks. I wired that up to the new deck and installed it under the seat. I can't wait to see how it sounds with the new speakers. It is the Rockford Fosgate RF 2.6X. I can't find a pic right now but will have actual pics when I finish the install (I left the camera out in the truck).
Amp setup as of Saturday (I just hooked up an old 6x9 in a box to get me through the weekend):
Today I went out to the boonies to pick up a new seat from Boheefus off of TTORA. When I got back my new speakers were waiting and so I pushed off work a little more and knocked out the install. Here we go...
One speaker installed, the other hole cut, and the first time it occurred to me to take pics

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Speaker installed. Yes, I slipped with the drill and poked a hole in my door panel. Yes, I am mad about that. I'll try to fix it later:
Sorry this came out fuzzy.. This is how I ran the speaker wire from the door. There is a hole that goes through the hinge so I just made it a little bigger and ran the wire behind the hinge so it wouldn't get pinched. That goop on there is silicone just in case:
Here's where it comes into the cab:
This is where I mounted the crossovers. Yeah, it's not ideal to have them that far away from the speakers but I think it'll be fine. They are mounted very solid with 2 self-tapping screws and are pretty much concealed by the seatbelt and kinda behind the seat:
Amp fully hooked up. I will probably clean it up a bit with some zip ties and stuff after I tweak on it a few days:
New stereo installed:
Other speaker installed:
Tweeter mounting (I just used velcro so it's easy to move if I need to and I didn't have to drill any holes.. I just tucked the wires behind the ends of the dash):
Cleaned out getting ready to install the seat: