I'm not a follower of forced induction .... but this thread likely has a lot of relevant info in it: https://forum.ih8mud.com/60-series-wagons/163559-can-you-turbo-3fe.html
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So build it and show us what we are missing then. Right now, you are stating theory.
I just question long term durability. These engines have a long stroke, with long rods, and heavy pistons on the end of them, and that's coupled with the grossly inadequate crankshaft support.
There's only 4 main bearings in these engines. You get enough cylinder pressure and that crank is going to start flexing like a wet noodle. 300 HP @ 4000 RPM is nearly 400 lb-ft at the crank. I think that's asking a lot from that bottom end.
I know a piggy-back system makes things easier, but what happens if the main EFI system or the piggy-back decides to pack it in while you're in full boost up a hill? You'll probably punch the bottom end right out of the engine with that much detonation.
That's not even mentioning what the poor A440F is going to do with that much torque being sent into it.
In my opinion, once the price mark start passing $1500, I automatically start leaning towards a complete engine swap. For around 2k you can start finding bread trucks (read 4bt cummins) chevy 350s, and **** have you seen how cheap rusty BJ/HJs are in Canada now?