I was wrenching with a buddy last week. Doing spark plugs and a few suspension things on his car.
Funny thing as he's a recent transplant from the snow belt. Common strategy was to slather anti-sieze on everything that had threads. My experience and research tells me it's to be used much more pointedly. Not taking a side, but I can certainly understand why for a vehicle used in corrosive vs arid environments.
I typically change over the wheels on my vehicle and my wife's car Spring and Fall -- snow tires go on in the Fall, come off in the Spring. I've done this on a 2002 Mercedes C240, 2003 4Runner, and 2010 Mercedes C300. If you don't put anti-seize on the hubs, the aluminum wheels stick to the hub. They can stick to the hub with enough force that I can't physically pull off the wheel. The only way for me to get the wheel off is to take a sledge hammer, slowly swing it horizontally under the vehicle so that the sledge hits the tire gently (not the wheel). That pops the wheel off the hub.
Once the wheel is off the hub, you will see white corrosion from the aluminum wheel stuck to the hub. It comes off with a stiff wire brush.
I put a thin coat of anti-seize on the hub (not the lugs) to prevent this. It doesn't take much and clearly you don't want grease flung out onto your brake rotors.
If you don't use anti-seize on your hubs and you get a flat, chances are you won't be able to get your wheel off your hub (unless you carry a very big hammer around with you).
Up here in the snow belt, you can assume that most every bolt under your vehicle will be rusted and stuck.