BTDT twice.
I lost the front left wheel off two separate cruisers, for two different reasons.
Once at 50mph, once at 75mph.
First one on my HDJ81 was about 30 miles after a tyre shop repaired a tyre for me. The only thing unusual I could see was that they greased wheel studs. Happened at 50mph as I turned onto a motorway.
Second was my HZJ105, again about 30miles after I had changed steel rims back to alloy after a weekend of wheeling and didn't think to clean a fine layer of dried mud off the hub. I think the mud wore away, and wheel nuts lost their torque.
Happened at 75 on a motorway, the wheel bounced over a rail, down an embankment, across a road used heavily by motorcyclists, and went 1/4 mile into the bush.
On both mine, all the studs were in tact. 1st time, I walked back along the road and found a couple of the wheel nuts. Both times, I robbed wheel nuts of other wheels to get me home.
Both times I ended up with a large flat spot ground onto the edge of the rotor, and dust guard.
After the first event, I've been anal about using a torque wrench to torque wheel nuts.
I've heard and read about numerous cases, seems to often be the front left