I haven’t had very many issues at all thus far. I have done all maintenance and the few repairs needed I have completed on my own with some great help and advice from some members of Mud.
Early on, there were two stereo related issues. I had excessive bass in the stereo and was able to correct that by replacing the factory JBL amp with a new one just like it. I also had the power antenna go out so I replaced it with a non-powered Tundra antenna.
I had an electrical issue that turned out to be a bad Odyssey battery. And, I also had a check engine light (P0155 code) come on at 88K miles that turned out to be a PS O2 sensor.
The only other mechanical issue that I have had is a broken CDL Actuator at Cruise Moab last year. On the second day of trails, the CDL light would not go off. So, I drove the final two days of trails with the Center Diff locked the whole time. After the last day of trails, I pulled the rear drive shaft and drove the 100 from Moab to Louisville, KY with no issues. Once home, I pulled the actuator and found it broken. I was able to source a used actuator assembly from a salvage yard for $140.00. List price was almost $600.00!
You can read more on this here.
One note of thanks to LexusBen again for all of his help in diagnosing my problem and spending a lot of time on his back, in the dirt on a dirty tarp, trying to get the actuator to release on my 100. Unbeknownst to either of us at the time that it was actually broken and not just bound up.

Thanks Ben!
Other than these items listed, I have had great reliability and feel very comfortable that my 100 will get me where I want to go and then get me home. It’s a great vehicle that does everything well. I can drive the family on long trips in style and comfort and at the same time, I can go to Moab and wheel some great trails.