I wouldn't recommend it. The 200-series is a heavy full size SUV that needs all the tire cross section it was fitted with, for safe handling and braking performance.
265s are the domain of mid-size SUVs IMO. An example of what you'll be giving up
The new LX600 rides on 265s, vs 200-series that is fitted wider 275/285 cross section tires. The 300-series generation is more weight and efficiency focused. On paper, it should have significant power and handling advantages with with less weight, modern design, significant better mid-range torque and straight line speed, and in a sport focused F-Sport trim. Yet it is the 200-series that posts better handling and braking numbers because of stronger overall traction from the larger contact patch. There's several flavors of 200-series - and it generally follows that the larger contact patch vs weight, provides better dynamic traction, leading to objectively stronger and safer braking and handling characteristics. The MT Figure Eight test is particularly telling.
It's also important to note that we often fit taller A/T tires and add more weight. All things that further compromise handling grip which is important to safety. My preference is to increase width to offset those other factors to keep a well balanced vehicle.
| LC200 HE | '15 LX570 | '17 LX570 | LX600 |
| Tire Size | 285/65R18 | 285/55R20 | 275/50R21 | 265/55R22 |
| Curb weight | 5,774 lbs | 6109 lbs | 6,230 lbs | 5,899 lbs |
| HP | 381 hp | 383 hp | 383 hp | 409 hp |
| 0-60 | 6.8 sec | 7.0 sec | 7.3 sec | 6.7 sec |
| Quarter Mile | 15.2 sec @ 91.2 mph | 15.4 sec @ 90.8 | 15.6 sec @ 89.9 mph | 15.0 sec @ 93.7mph |
| Braking 60-0 | 121 ft | 125 ft | 118 ft | 128 ft |
| Lateral Acceleration | 0.75 g | 0.78 g | 0.76 g | 0.75 g |
| MT Figure Eight | 27.8 sec @ 0.61 g | 27.9 sec @ 0.66 g | 28.2 sec @ 0.61 g | 28.5 sec @ 0.59 g |
