Clearly the A440F worked with the Isuzu but I had six reasons to go with the AW450:
1) I had essentially a brand new AW450 so I preferred to use it rather than the A440F with more than 100K miles on it.
2) The AW450 that I have came with a PTO that I would like to use.
3) I felt that the AW450 would work better with the Isuzu diesel as it was designed with shift points to match the torque curve of the diesel.
4) The AW450 is an electronically-controlled transmission which I prefer and will lock up the torque converter in 2nd, 3rd, and OD as it comes from the factory. Because it is electronically-controlled, it is easy to add torque converter lockup in 1st gear also.
5) Because it is electronically-controlled, I don't have to deal with the touchy TV cable like on the A440F.
6) And finally, it is heavier duty than both the A440F and A442F (See Fromage's thread).
7) Shorter 1st and taller 4th gear ratios as well...

For some reason that I don't understand, when Isuzu designed the 4H series, they placed the gear train that drives the IP, cam, oil pump, and power steering pump at the back of the engine rather than at the front as in the 4BD series and most other engines. This resulted in a totally different back end and also results in the problem of the starter location.
Better coolant flow in/out of the water pump without having all the gear train to go around?
Puts the oil pump at the rear closer to the sump, minimally reducing the time it takes on a semi-dry start for the oil to get into the pump and then into the motor?
Just a wild guesses on my part.