I can't opine on the GX550 specifically, but living in the same neck of the woods as you and wheeling around here a lot (as well as going out to CO and UT), I've ran nothing but SL-rated tires on my rig for the past 4 years. Zero issues with flats, punctures, or sidewall damage. We also tow a camper all the time, and the SLs do just fine.
IMO there should be no need for E-rated tires on any Toyota SUV unless it is a dedicated trail rig. I'd stick with a high-quality SL if they come in your size and C if they don't. If you are worried about punctures, it would be better to add onboard air and carry a tire repair kit and some gluetreads (as I do, but haven't yet needed to use).
I agree and will add while load range "E" tires have very strong 10-ply (if I am not mistaken) sidewalls, they suck at deforming and grabbing when aired down. I run BFG Mud-Terrain T/A KM3 33" E's on my Xterra simply because they were the only available tires in that pizza cutter size (255 85 16); they perform well and resist slashes and punctures quite well, however, when airing down to 10-psi or lower you can barely see any sidewall flex.
One might say "what's the problem?" and my answer is: when running SL, XL, "C" range, the tires actually deform in a positive way. I am not solely referring to contact patch (fore-aft), but to the tires grabbing around rocks, roots etc. Seems counterintuitive, however, I think the more pliable deformation works better for the tough trails I do at Uwharrie when facing mud, rocks, roots, steep inclines and declines.
I do see the benefit of "E" range for "overloading" or driving on unimproved roads in the wilderness and camping due to the robust tire construction.
Look at the downsides of load range "E":
-not engineered for your light duty vehicle in most cases (excluding HD trucks and SUV's)
-very heavy (more mass to twist and harder on your back for wheel changes)
-significantly more expensive
-not the best choice for maximum traction in mixed off roading involving rock crawling/climbing
-harsher ride
-availability when traveling (referring to replacements as I have had issues with niche sizes in the past)
I guess it depends on individual use case. I have run them at least 3 times on SUV's mainly because of the sizes I was hunting. I have lost tires off trail on the road trips out west (highway) due to sidewall failure from puncture; so I see the draw to an overbuilt sidewall. I still believe for my uses the OEM SL, XL, or "C" range would be the best tires to use.