I've done it a few times, with a short wheelbase, I would be very couscous. That road can be slicker than snot... Have breakfast and dinner at Coldfoot, I wouldn't stay there though. Right up the road is Wiseman, there are a couple B&B's, and the town has a great historical museum. Also the Fish and Wildlife visitors center is a diamond in the ruff, definitely a must stop. The weather is very unpredictable, typical Alaskan summer... North of Atitgun Pass the road has been in absolutely horrid conditions. I wouldn't not be surprised at all, if you break something in this stretch of road, it's beat to dog sh*t... If you plan on doing this with a 40 series, have it sealed as best you can, you're going to get mud literally everywhere. Mud mixed with a stiffener called calcium carbonate also makes it a pain in the ass to wash off...
Depending on your cell phone carrier, there is also cell service in the vicinity of Coldfoot.