It's taken me some time to set up my 670 cfm Truck Avenger on my mild 350.
The carb is set up very rich to make it universal. If it won't run a vehicle out of the box, then you've got some serious problems not related to the carb. Gas mileage was bad.
I dropped the primary jets from 68 to 64. This brought the mileage up a bit, and the plugs look normal now (they were sooty black before). But it also caused an off idle stuble, so I increased the accelerator nozzle from .028 to .032. This solved that problem.
The secondaries are jetted extremely rich. I changed them from 89 to 79. That helped, and it may be possible to tweak that some more.
I did increase the power valve from 2.5 to 6.5. The vacuum gauge showed that I never even got to 2.5, even under WOT. Might as well have put a solid plug in there. And that's the point - you have to jet way up when you replace the power valve with a solid plug. Up to 8 to 12 jet sizes, depending on the carb size. So this went hand in hand with dropping the secondary jet size from 89 to 79.
I still haven't gotten the mileage to 10 mpg. The primaries may need to either be jetted up slightly, like to 76. And I might try out an 8.5 power valve.
If I had a blank slate to start with, I think I'd rather have the 470 cfm Truck Avenger. Being smaller, it should have better low end throttle response. And the flow velocity should be higher, which should mean better mixture.
Or, I'd rather get a rebuilt Rochester. Something for a 350 truck from the mid-70's ought to be close enough. The Rochester is not as easy to work on as the Holley, but they do seem to get better gas mileage.