Something I think happens more with thinner leaves will be breakage. Even in the junkyard looking at thicker leaves with vehicles that have been in serious wrecks I haven't found the domestic thicker leaves cracked. Doesn't mean it won't happen but using a thicker leaf will reduce those chance of cracks. I've been suprised to see so many cruiser leaves cracked here on the boards from normal useage and old age. I have no doubts that the OMEs are stronger and better than the stock cruiser stuff.
On my setup I've used the longest leaves I could find which included chevy 63's in the rear and a hybrid pack up front with a 58" main leaf (second tuning). I've had a comment offroad that it does ride smooth and it definitely flexes well. I had the chevys in a previous rig and they worked very well. I've been happy with their performance on my 60 as well. I do everything with my rig, DD, tow, wheel so the added strength with the massive overload leaf on the rear was important to me. I'm also controlling big, fat, and wide tires. For me, the longer leaves have worked out nicely.