Happened to me once on a long trip, was going about 160, heard the noise, felt the rumble, slowed to about 80, opened windows, checked wheels, nothing, then my back left wheel came off, the axle started dragging on the road, the wheel headed straight for a crowd on the roadside, they parted like the Red Sea, luckily no one was hit, the wheel hit a rock at about a 45 degree angle and flew straight up, and landed so we could find it, when I looked at the axle there were no wheel nuts left. I then checked all the wheels as I had asked the service centre to do a tyre rotation, and brakes check, all nuts were looses and I tightened all the remaining 3 wheels' nuts. Luckily someone we had met 5 years before recognized my wife and stopped to pick up my family & they went back to their house whilst I remained and patched up the drum, borrowed nuts from other rims, replaced the spring in the drum brakes that had disappeared when the drum decided to follow suit after the wheel, and managed to get the vehicle to the great people that were looking after my family... So much could have gone differently & so much could have been much worse... we thanked God that night.