Plenty of cheerleaders on this thread. I will express the dissenting opinion:
The 100 series LCs are solid well-engineered luxury four-wheel-drive vehicles,
not magic carpets that will run forever on pixie dust.
250k is a lot of miles, and if you buy an LC with 250k miles on it for use as your daily driver, you should have some serious scrilla set aside to pay for repairs, which will be frequent and expensive.
If the maintenance was done according to schedule, as you state, you will be due for a timing belt and water pump within the next 20k miles ($1000). Also, plan on replacing the brake booster assembly ($2000), brake pads ($200), and maybe the calipers ($800). The starter is known to fail and will set you back $275 for the OEM part. The steering rack ($2000) and CVs ($400) are probably both leaking, and the transmission will cost about $3000 to replace when it fails. These are guesstimated prices if you were to have the work done at a Toyota dealership. Obviously, you could save a lot of money if you enjoy working on your own vehicles. You could probably find somebody to do the work for you cheap, but unless you know they are good, you could run into situations like this:
https://forum.ih8mud.com/showpost.php?p=9087036&postcount=8
And that's my point, you could use a 2001 LC with 250k miles as your daily driver, but you should not buy that truck unless you enjoy repairing vehicles and are pretty confident in your diagnostics and wrenching skills.
My advice is to save-up another 2 or 3 thousand dollars and get a lower mileage example. Financially, you will come out ahead in the long run, and it will save you a lot of headaches and down time if you wait for one with lower miles.
-End dissenting opinion-
I agree with Klaus that the condition of the truck and the maintenance record are much more important than the number of miles on the odometer, but still, if you buy one with 250k you better be ready to work on it.