My philosophy may be different from others. In my mind, after researching basically every known truck tires, i am down to two tires...unless something new comes out. I chose KO2 because i do off-road and i want peace of mind regarding puncture resistance. BUT, i chose stock size (285/60/18) to avoid the issues with going with a taller tires (zapping acceleration esp on highway passes, wear & tear, etc.). Ground clearance is not a big issue for me...stock 9.8" clearance and approach/departure are fine for my needs. Having to change tire in the middle of desert heat or freezing temp is not fun nor safe for me (and family).
BUT, i may go to Michelin Defender LT next time...but to do that i would have to upsize to 285/65/18, which is off spec and very expensive ($$$$ + adding spare). But since Defender LT is around 7 lbs lighter than my stock sized KO2, i figure that the stress on components and acceleration difference won't be much different. Defender obviously has less aggressive thread for off-roading. The sidewall is TWO ply...but from everything that i have read, it is one tough-ass tire. You can air it down without issue. The Evertread is about as tough as anything out there. The sidewall is very strong for a 2-ply carcass.
Yokohama G015 was also up there with Defender...until recent TireRack comparison (above) showed that it's fuel economy (in P-metric no less) was outright shameful! Imagine how bad it is with LT G015! I know that G015 excel at other aspects...but fuel economy worst than KO2 is unacceptable IMHO.
Coopers...when i researched them...i love that they are USA. Tread looks good. BUT reading more and more into them, it seems like it is a crapshoot. Some people love them. Some hated them because of balance issues etc.. And the ratio b/w happy and piss-off seems to be closer than with other tires.
Falkens are great value but they are heavy as hell due to using regular steel belts/plies/cords to keep prices low...the more expensive brands (basically everyone else) use high-tensile steel plies which offer same strength but much lighter in weight. Even though they roll over the ply for better sidewall protection, i have read of several sidewall puncture stories on other forums. And you know me and tire weight! LOL
In addition, for better or worst, i trust big name tire OEMs...Bridgestone, Michelin (and BFG), Goodyear, Yokohama, Continental...over the smaller brands (Falken, Nitto, etc.). But that's just me...i am a brand whore.