I use Yakima Skybox 12 with no discernible increase in wind noise. On my rig, opening the sunshade generates more noise than the cargo box. The Skybox 12 is a long, skinny bullet compared to most cargo boxes. Here are a couple pics from a 2700 mi summer road trip with six people in the truck (including me) averaged 16.4 mpg running 75-80 mph.
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The tailgate spoiler is big and in the open position hits bottom of the cargo box. To address that, I install my Yakima rear cross bar to the truck's roof rails to lift the back of the cargo box up a few inches to clear the spoiler.
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I purchased the Skybox so I can load the cargo box + 4 bikes on the roof. Packed for a family camping trip.
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Even on my Passat.
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