I would like to add, if you can spare the vacation, come a couple days early so your body can acclimate to the higher altitude (5K - 8K feet) before you even consider heading up to 8K+. I have a friend from coastal VA that came to visit a few times. We went to Mesa Verde on her second day here and had to turn right back around when we got to the visitor center (~7,500 ft) but she was fine at 5K feet. On another trip. we waited a few days before going there and she was fine.
I've been up at 12k a few times, and I did have headaches the first few days.
Plan for me is to be in Ouray Thursday mid-day, hope to get acclimated by the time we start making runs.