The 5.3 and the 4L60E have their own individual stand-alone computers and each can be flashed inexpensively for economy, power, shift points, shift firmness, etc. For a newer engine, it's almost plug and play to retrofit them into a different vehicle. Gas pedal linkage, some Toyota sensors in the engine to work with the Toyota gauges, some custom mounts and drive shafts and you're good to go usually. Personally I'd go with the 4L80E instead since the 4L60E is kinda weak in a heavy truck, but otherwise it's a great combination. Of course that's an easy upgrade when the 4l60E goes if it comes to that. I'm looking forward to the progress.