Need more info! motor? trans? gearing? t-cases? weight? wheeling style? rocks? mud? trails?
As said, its been done, you will break. But I wheeled for a long time with a 4runner on 42 Iroc's stock rear end, stock rear shafts, 4cyl 3rds, longs, chromo hub gears. It stayed together, but had a 400k mile 22re with maybe 50 hp. (he is Joez on the board) He also knew how to drive it to keep it together, no shock loading, etc...
I would not jump to chromo rear shafts just yet. He was on stockers and never broke them (they rarely break). I suspect it could have been due to their ability to twist 100*+ and come back. I would do a rear disc conversion and carry a spare in the beginning to see how the rear shafts hold up.
His truck was very impressive and stayed together quite well.
Ive gone through a lot of 8" 3rds and I still believe that the factory 4.88 v6 3rd could be the strongest of them all, maybe stronger than the high pinion. Could be the inherit beef, could be the toyota set up, could be the fact that once I pull them (for $100!!!!) from the junk yard they are nice and broke in....who knows, but Ive yet to break one, and I have never heard of one breaking. Don't get me wrong I'm sure they have been broken plenty, but its rare enough that I haven't stumbled on the claim.