Since I believe that is a silicone base, I just try not to use anything in a system that it is not designed for. So, I would only use water based products in my cooling system. That's why I use antifreeze as a lubricant for hoses on the cooling system.
There are a few folks that disagree with...
The hoses under the truck that connect to the heater hard lines will require 1/2" hoses and they are a TIGHT fit. You'll need to smear antifreeze inside them and on the tube before you shove them on.
You can replace the entire hard /soft lines on the LOWER section to the rear heater without...