Our Highlander has that refrigerant then, and it works totally fine (ice-cold AC like my R134A GX470).2021 was the cutover model year for R1234yf
To the problem above, my money is on some kind of a blend door/actuator problem. Something may have fallen into one of the vents and jammed things up. On a GX470 you have to remove the dash to get to some, but not all, of the actuators. Not sure where they are on a 460 or how hard they are to get to.