Propane makes sense for an urban vehicle, particularly a work or delivery vehicle.
I can't see it making sense for an off-road or vacation vehicle.
1. The propane tank weighs a considerable amount, because it is pressurized.
2. Gallon for gallon, you get less range with propane than you with gasoline, and less power as well. This is because propane has less BTU than gasoline.
3. Propane is not as plentiful to find as gasoline, particularly in the boondocks. And, some stations refuse to pump propane into vehicle fuel tanks, because of road tax issues. Some states have no issue with propane being pumped, but charge more for registration to make up for lost gasoline road taxes.
4. You can carry spare propane fuel tanks, but these are your BBQ style tanks, and you have to have your system modified to allow them to be plumbed in.
5. It is possible to run a dual propane and gasoline system using a carb bonnet and a solenoid to shut off the gasoline delivery. This is a compromise but it can work. However, it preclused building the engine with higher compression to try to extract a bit more work out of the low BTU of the propane, since propane has a higher effective "octane" rating, if you will, than gasoline. Unless you want to use a higher grade of gasoline, of course.
6. If you think unleaded gasoline is hard on valve seats, try propane. It has zero lubricity. That was a major cause of problems with older fleet delivery trucks that were converted to propane in the 1970's. Many required stellite valve seat inserts and very high quality valves. I'm not a fan of valve seat inserts because they tend to raise valve temps, because they don't convect heat as good as the unmolested head does.
7. Propane DOES respond very well to turbocharging. Being a gas, and being that it's in effect a cooling charge, it works to lower the dense and heated air charge.
8. Propane works well regardless of what angle the engine is at.
The latter two might be pluses to a trailered rock crawler, especially one with a dry sump oiling system. Other than that, I can't see propane being worth the hassle.