The problem with this leak is that anything you try requires you to drain almost half of your coolant (unless some 'mud wizards have a better idea?). If the botom of the pipe is corroded on the inside like mine was, you will need oversize o-rings. The 16268 nipple was surprisingly clean in my case and would not come out.
Currently on my vehicle I have the original 16351 pipe with the bottom polished, a new o-ring at the top, an oversize o-ring at the bottom with ANOTHER even larger o-ring squashed at the top of the nipple and the original o-ring at the bottom of the original nipple. This joint (top of nipple/bottom of pipe) did leak (about 1/3 of the total leak in that area) despite new factory o-rings and does not leak now with oversize o-rings. If you buy the parts from a local dealer to have on hand so you don't have to keep draining coolant, you may be able to return them if you don't need them. That was my thinking, but I was embarrassed to return even more parts after my whole head gasket saga.
Best wishes!
P.S. I am still unclear about the wisdom of applying a thin coat of silicone to joints like this. I greased up a lot of stuff, but this particular joint on this particular go around is dry.