ginmtb
'74 FJ40 - my first!
Vehicle choice for me will vary based on time of year. I'd like to suggest that the route detour from the coast central valley of CA over the Sierra Nevadas past Lake Tahoe and then down the Eastern Sierras. WAY more scenic/rustic, and way more off road opportunities. You could then shoot across 190 into Death Valley and on to LV that way, or keep going south and take the 58, or as @thorslc1977 suggests, a parallel route to LV.
I'm good driving to Tahoe! Definitely more scenic than the drive to SLO. I was thinking I'd stop at every mission along the way and maybe camp at the Pinnacles. But I'm open!