500awhp or 500 crank horse power? This is a huge difference in the 80 because there is such a huge parasitic drivetrain loss. 500awhp is likely just on the outside of what is achievable with pump gas, even with some engine work. In most circles it's assumed that the max boost on pump gas before serious detonation occurs is around 20 maybe 22psi. 22psi is on the high end but with a good tune, an effective intercooler and some meth injection I could see it working.
Anything above that and you need to look at different fuels. In the past you would be stuck with very expensive race gases, but now with E85, you get the high octane rating and the better cooling aspect because you're using 30-35% more fuel. This also leads to massive torque increases because of extra exhaust gas volume and the ability to retard timing with all that extra octane. The issue is that because it does require that 30-35% more fuel per hp, is that now your fuel system isn't up to task and for that 500awhp target you will need large alcohol fuel compliant injectors, a larger fuel pump(s), and perhaps even a larger fuel line.
I think where I am sitting on this build is just about perfect, for most people. I am sitting at close to 400awhp, I run pump gas, not as many parts needed to be changed out, I am in the 6 second club for 0-60mph with a 6000+lb truck, it has been very reliable and I haven't had any transmission or drivetrain issues up to this point......
