ideally you would want your tweeters in your a pillar pointing at you. But sometimes that is not feasible. It has been done, and done well. Luke111 has done a lot of custom stereo work in his 80. The last place you want to put the tweeters is down low in the door next to the separate. The happy medium usually ends up with people putting them in the top of the door. I have mine in the top of the door and it sounds good I have no complaints.
And the way wiring speakers works is:
If you wire two speakers that are 4ohms together in series (input to +, out the -, to the + one the second speaker to the -, and back to the amp) you have a 4+4 = 8ohm load
If you wire two speakers that are 4ohms together in parallel (- to - on each speaker, + to + on each speaker) you have 1/4 + 1/4 = 1/.5 = 2
This is especially important when you are choosing equipment and you know your amp provides the best power at 2 ohms. If you get (2) 4 ohms subs and wire them in series you have 4+4=8ohm load and lose out on amplifier efficiency and if you wire them in parallel you have a 1/4+1/4 = 1/.5 = 2ohms and is the best way to wire them. That is why you will often see the same subwoofer offered in multiple resistances so that you can plan how you will setup and wire them to work best with your amplifier and how many subs you want.